Upstate South Carolina Vacations from $404
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Your Upstate South Carolina Vacation
When adventure calls, answer it with a tailor-made vacation package to Upstate South Carolina. Wherever it is you're going and whatever your plans are, prepare to experience a destination with plenty to offer. Start your trip to Upstate South Carolina with a few nights in Greenville visiting popular sights like Falls Park on the Reedy and Bon Secours Wellness Arena. Spartanburg is another city that draws crowds from far and wide. WestGate Mall and Tyger River Park are two of the top places to see in this destination. Find some travel buddies and start packing, because your Upstate South Carolina vacation is just a few clicks away with Expedia.
The Latest Upstate South Carolina vacation packages
Price found within the past 48 hours. Click for updated prices.
Holiday Inn Asheville East-Blue Ridge PKWY by IHG
Price was $605, price is now $404 per person
$404
per person
Oct 24 - Oct 27
found 1 day ago
Roundtrip non-stop flight included
Boston (BOS) to Asheville (AVL)
9.4/10 Exceptional! (1,005 reviews)
The property was clean and the staff were friendly.
Reviewed on Aug 20, 2025
Hilton Garden Inn Asheville Downtown
Downtown Asheville
Save 100% on your flight
Price was $800, price is now $509 per person
$509
per person
Oct 24 - Oct 27
found 1 day ago
Roundtrip non-stop flight included
Boston (BOS) to Asheville (AVL)
9.2/10 Wonderful! (856 reviews)
Walking distance to downtown was very convenient.
Reviewed on Aug 21, 2025
Grand Bohemian Lodge Asheville, Autograph Collection®
Biltmore Village
Save 100% on your flight
Price was $1,205, price is now $822 per person
$822
per person
Oct 24 - Oct 27
found 1 day ago
Roundtrip non-stop flight included
Boston (BOS) to Asheville (AVL)
9.2/10 Wonderful! (870 reviews)
My wife and I loved this hotel. Right at the front entrance to Biltmore which is why we came to Asheville. Staff were nice and professional. The food there was excellent. We really enjoyed the room. We will stay here again.
Reviewed on Jun 21, 2025
Kimpton Hotel Arras by IHG
Downtown Asheville
Save 100% on your flight
Price was $1,092, price is now $784 per person
$784
per person
Oct 24 - Oct 27
found 1 day ago
Roundtrip non-stop flight included
Boston (BOS) to Asheville (AVL)
9.6/10 Exceptional! (1,015 reviews)
Great hotel, superb service!
Reviewed on Aug 17, 2025
The Restoration Asheville
Downtown Asheville
Save 100% on your flight
Price was $1,451, price is now $1,041 per person
$1,041
per person
Oct 24 - Oct 27
found 1 day ago
Roundtrip non-stop flight included
Boston (BOS) to Asheville (AVL)
9.8/10 Exceptional! (895 reviews)
The property is beautiful and clean. Service is excellent. I would stay here again.
Reviewed on Aug 21, 2025
Don't see what you're looking for?
See all available trips from Columbus to Upstate South Carolina
View all tripsWhere to stay in Upstate South Carolina
Find the best Upstate South Carolina areas and neighborhoods for the activities you enjoy most. Learn more about Upstate South Carolina
Greenville Downtown
3 out of top 10 points of interest in this area
5/5(654 area reviews)
The ample dining options and beautiful river views are top of the list for many visitors to Greenville Downtown. A stop by The Peace Center or Bon Secours Wellness Arena might round out your trip.
Discover the most popular places to visit in Upstate South Carolina
Clemson University
Walk around the campus of Clemson University, a top university in Clemson. Experience the area's theater scene or attend a football game.
Falls Park on the Reedy
Falls Park on the Reedy is just one of the places to see in Greenville, so why not enjoy the other things to explore during your travels? Experience the acclaimed theater scene or attend a sporting event in this family-friendly area.
Fred W. Symmes Chapel
You can find out about the history of Cleveland when you stop by Fred W. Symmes Chapel. Wander the lakeside and forest in this relaxing area.
What to do in Upstate South Carolina
Epic City Scavenger Hunt in Garden Grove by Operation City Quest
$10
per adult
Small-Group Walking Tour in Greenville with Breakfast
$80
per adult
100% of travellers recommend
Upstate South Carolina Hotel Deals
Crowne Plaza Hotel Greenville-I-385-Roper Mtn Rd by IHG
851 Congaree Rd, Greenville, SC
Fully refundable
$95 nightly
The price is $105 total per night from Aug 31 to Sep 1
$105 total
Aug 31 - Sep 1
Total with taxes and fees
8.4/10 Very Good! (1,000 reviews)
"Great hotel , would stay again ."
Reviewed on Aug 16, 2025
Hyatt Regency Greenville
220 N Main St, Greenville, SC
Fully refundableReserve now, pay when you stay
$139 nightly
The price is $153 total per night from Sep 1 to Sep 2
$153 total
Sep 1 - Sep 2
Total with taxes and fees
8.6/10 Excellent! (1,002 reviews)
"great"
Reviewed on Aug 21, 2025
Hilton Greenville
45 W Orchard Park Dr, Greenville, SC
Fully refundableReserve now, pay when you stay
$90 nightly
The price is $99 total per night from Sep 4 to Sep 5
$99 total
Sep 4 - Sep 5
Total with taxes and fees
8/10 Very Good! (1,008 reviews)
"It was a very well kept hotel."
Reviewed on Aug 22, 2025
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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- CU Intl. Center for Automotive Research
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- Rockwood Park
- Frankie's Fun Park
- Gravitopia Trampoline Arena
- Green Forest Park
- McAlister Square
- Old Towne Shopping Center
- 7th Inning Splash Waterpark
- Lakeside Park
- Lewis Plaza Shopping Center
- Runway Park at GMU
- Prisma Health Greenville Memorial Hospital
- Roper Mountain Science Center
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.