Upstate South Carolina Vacations from $315

Book a Hotel + Flight or Car together to unlock savings

Photo by Victoria S
  • Plan, book, travel with confidence

  • payments icon

    Better together

    Save up to $1,045 when you book a flight and hotel together*
    lob hotels icon

    Find the right fit

    With over 300,000 hotels worldwide, it's easy to create a perfect package
    lob packages icon

    Rest easy

    Plan, book, and manage your trip all in one place

Your Upstate South Carolina Vacation

When adventure calls, answer it with a tailor-made vacation package to Upstate South Carolina. Wherever it is you're going and whatever your plans are, prepare to experience a destination with plenty to offer. Start your trip to Upstate South Carolina with a few nights in Greenville visiting popular sights like Falls Park on the Reedy and Bon Secours Wellness Arena. Spartanburg is another city that draws crowds from far and wide. WestGate Mall and Tyger River Park are two of the top places to see in this destination. Find some travel buddies and start packing, because your Upstate South Carolina vacation is just a few clicks away with Expedia.

The Latest Upstate South Carolina vacation packages

Price found within the past 48 hours. Click for updated prices.
Holiday Inn Asheville East-Blue Ridge PKWY by IHG
Hilton Garden Inn Asheville Downtown
Bluegreen Vacations Blue Ridge Village an Ascend Resort
Grand Bohemian Lodge Asheville, Autograph Collection®
The Windsor Boutique Hotel
Don't see what you're looking for?
See all available trips from Columbus to Upstate South Carolina
View all trips

Where to stay in Upstate South Carolina

Find the best Upstate South Carolina areas and neighborhoods for the activities you enjoy most. Learn more about Upstate South Carolina

Discover the most popular places to visit in Upstate South Carolina

What to do in Upstate South Carolina

Upstate South Carolina Hotel Deals

Hilton Greenville

Hilton Greenville

3.5 out of 5
45 W Orchard Park Dr, Greenville, SC
Fully refundableReserve now, pay when you stay
$84 nightly
The price is $93 total per night from Aug 21 to Aug 22
$93 total
Aug 21 - Aug 22
Total includes taxes and fees
8/10 Very Good! (1,003 reviews)
"Everything was excellent."

Reviewed on Aug 15, 2025

Hilton Greenville
Hyatt Regency Greenville

Hyatt Regency Greenville

3.5 out of 5
220 N Main St, Greenville, SC
Fully refundableReserve now, pay when you stay
$139 nightly
The price is $153 total per night from Aug 24 to Aug 25
$153 total
Aug 24 - Aug 25
Total includes taxes and fees
8.6/10 Excellent! (1,001 reviews)
"The restaurant was under construction and had limited menu and no food service at bar The food I had was very tasty"

Reviewed on Aug 11, 2025

Hyatt Regency Greenville
Crowne Plaza Hotel Greenville-I-385-Roper Mtn Rd by IHG

Crowne Plaza Hotel Greenville-I-385-Roper Mtn Rd by IHG

3.5 out of 5
851 Congaree Rd, Greenville, SC
Fully refundable
$95 nightly
The price is $105 total per night from Aug 22 to Aug 23
$105 total
Aug 22 - Aug 23
Total includes taxes and fees
8.4/10 Very Good! (1,000 reviews)
"Staff was great hotel was clean"

Reviewed on Aug 8, 2025

Crowne Plaza Hotel Greenville-I-385-Roper Mtn Rd by IHG
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

More vacations you might like

* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.