Title: Upstate South Carolina Vacation Packages 2026 from $541 | Expedia.com [Upstate South Carolina Travel Guide](https://expedia.com/Upstate-South-Carolina.dx6057939)[Hotels in Upstate South Carolina](https://expedia.com/Upstate-South-Carolina-Hotels.d6057939.Travel-Guide-Hotels)[Vacation Rentals in Upstate South Carolina](https://expedia.com/Upstate-South-Carolina-Vacation-Rentals.d6057939.Travel-Guide-VacationRentals)[Flights to Upstate South Carolina](https://expedia.com/Cheap-Flights-To-Upstate-South-Carolina.d6057939.Travel-Guide-Flights)[Things to do in Upstate South Carolina](https://expedia.com/Things-To-Do-In-Upstate-South-Carolina.d6057939.Travel-Guide-Activities)[Car Rentals in Upstate South Carolina](https://expedia.com/Car-Rentals-In-Upstate-South-Carolina.d6057939.Car-Rental-Guide) ![](https://images.trvl-media.com/place/144669/e945b35d-16b4-408c-818b-68622e164446.jpg?impolicy=fcrop&w=1200&h=300&q=medium) # Upstate South Carolina Vacations from $541 ## Book a Hotel + Flight or Car together to unlock savings Photo by RVLuckyorWhat - ## Plan, book, travel with confidence - ### Better together Save up to $1,045 when you book a flight and hotel together\* - ### Find the right fit With over 300,000 hotels worldwide, it's easy to create a perfect package - ### Rest easy Plan, book, and manage your trip all in one place ### Your Upstate South Carolina Vacation When adventure calls, answer it with a tailor-made vacation package to Upstate South Carolina. Wherever it is you're going and whatever your plans are, prepare to experience a destination with plenty to offer. Start your trip to Upstate South Carolina with a few nights in [Greenville](https://www.expedia.com/Greenville.d1388.Destination-Travel-Guides) visiting popular sights like Falls Park on the Reedy and Bon Secours Wellness Arena. [Spartanburg](https://www.expedia.com/Spartanburg.d9787.Destination-Travel-Guides) is another city that draws crowds from far and wide. WestGate Mall and Tyger River Park are two of the top places to see in this destination. Find some travel buddies and start packing, because your Upstate South Carolina vacation is just a few clicks away with Expedia. ## The Latest Upstate South Carolina vacation packages Price found within the past 48 hours. Click for updated prices. ![The Radical Asheville, Tapestry Collection by Hilton](https://images.trvl-media.com/lodging/91000000/90810000/90809800/90809737/0732ad16_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) ### The Radical Asheville, Tapestry Collection by Hilton River Arts District $541 per person May 27 - May 30 found 6 hours ago Roundtrip non-stop flight included Boston (BOS) to Asheville (AVL) 9.6/10 Exceptional! (516 reviews) I love the individually designed rooms. The decor is awesome almost club like we will absolutely stay there again. Staff was very friendly and helpful. Reviewed on Mar 23, 2026 ![Pinners Compound- 4 BR hot tub fire pit](https://images.trvl-media.com/lodging/96000000/95360000/95353500/95353482/c9f58154_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) ### Pinners Compound- 4 BR hot tub fire pit South Asheville Save 100% on your flight $1,082 per person May 15 - May 18 found 1 day ago Roundtrip flight included Chicago (ORD) to Asheville (AVL) No reviews ![The Restoration Asheville](https://images.trvl-media.com/lodging/76000000/75610000/75600300/75600240/2af742a7_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) ### The Restoration Asheville Downtown Asheville Save 100% on your flight $1,005 per person May 15 - May 18 found 1 day ago Roundtrip flight included Chicago (ORD) to Asheville (AVL) 9.8/10 Exceptional! (1,156 reviews) Easy to walk everywhere from the hotel. Great bar and game room downstairs Reviewed on Mar 24, 2026 ![The Windsor Boutique Hotel](https://images.trvl-media.com/lodging/10000000/9490000/9487700/9487610/761229c3_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) ### The Windsor Boutique Hotel Downtown Asheville $759 per person May 27 - May 30 found 6 hours ago Roundtrip non-stop flight included Boston (BOS) to Asheville (AVL) 9.8/10 Exceptional! (578 reviews) Satisfied with our stay. No problems. Reviewed on Mar 25, 2026 ![Grand Bohemian Lodge Asheville, Autograph Collection®](https://images.trvl-media.com/lodging/3000000/2210000/2201800/2201799/0a0ae2ec_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) ### Grand Bohemian Lodge Asheville, Autograph Collection® Biltmore Village $639 per person May 27 - May 30 found 6 hours ago Roundtrip non-stop flight included Boston (BOS) to Asheville (AVL) 9.2/10 Wonderful! (918 reviews) Beautiful property and very close to Biltmore Estate. Reviewed on Mar 24, 2026 Don't see what you're looking for? See all available trips from Columbus to Upstate South Carolina [View all trips](https://expedia.com/go/package/search/FlightHotel/2026-04-26/2026-05-03/?FromAirport=Columbus,%20Ohio,%20United%20States%20of%20America&Destination=GSP&NumRoom=1&NumAdult=2&NumChild=0&paandie=true) ## Where to stay in Upstate South Carolina Find the best Upstate South Carolina areas and neighborhoods for the activities you enjoy most. [Learn more about Upstate South Carolina](https://expedia.com/Upstate-South-Carolina.dx6057939) ![Always thinking on how I traveled half way across the world just to come and study. Sometimes I think of home and I miss it sooo much. But, this is the area I have lived for the last 3 years. This is the home far from home. I call this home, not because I have family here. It is where I have met so many wonderful people in this city. This is my #adventure from one side of the world to here!](https://images.trvl-media.com/place/1388/cd6e82af-6f0e-4f28-bd90-dc864c25ddac.jpg?impolicy=fcrop&w=350&h=192&q=medium) ### Greenville Downtown 2 out of top 10 points of interest in this area 5/5(657 area reviews) The ample dining options and beautiful river views are top of the list for many visitors to Greenville Downtown. A stop by The Peace Center or Bon Secours Wellness Arena might round out your trip. [Find hotel + flight trips in Greenville Downtown](https://expedia.com/go/package/search/FlightHotel/?FromAirport=Downtown%20Columbus,%20Columbus,%20Ohio,%20United%20States%20of%20America&Destination=Greenville%20Downtown&DestID=6348006&DaysInFuture=30&StayLength=7&rfrr=TG.LP.Dest.PKG.Neighborhoods) ![Default Image](https://images.trvl-media.com/media/content/expus/graphics/deals/TE_Clouds_card_r1.jpg?impolicy=fcrop&w=350&h=192&q=medium) ### Nicholtown If you're spending some time in Nicholtown, Pleasantburg Shopping Center and Swamp Rabbit Trail are top sights worth seeing. [Find hotel + flight trips in Nicholtown](https://expedia.com/go/package/search/FlightHotel/?FromAirport=Downtown%20Columbus,%20Columbus,%20Ohio,%20United%20States%20of%20America&Destination=Nicholtown&DestID=944322769370443776&DaysInFuture=30&StayLength=7&rfrr=TG.LP.Dest.PKG.Neighborhoods) ![Greenville - Spartanburg](https://images.trvl-media.com/place/6035267/cb556cb0-09f4-48a1-92a0-474aceebaeea.jpg?impolicy=fcrop&w=350&h=192&q=medium) ### Overbrook Historic District While Overbrook Historic District might not have many sights to explore, venturing just a little farther will lead you to top things to see and do like Beattie House and Bon Secours Wellness Arena. [Find hotel + flight trips in Overbrook Historic District](https://expedia.com/go/package/search/FlightHotel/?FromAirport=Downtown%20Columbus,%20Columbus,%20Ohio,%20United%20States%20of%20America&Destination=Overbrook%20Historic%20District&DestID=944230627130175488&DaysInFuture=30&StayLength=7&rfrr=TG.LP.Dest.PKG.Neighborhoods) ![Krissy Simmons](https://images.trvl-media.com/place/6348163/68b54b76-2321-4a98-9351-703daf9d97e1.jpg?impolicy=fcrop&w=350&h=192&q=medium) ### West End Arts and entertainment thrive in this Greenville neighborhood, with cultural events at the Peace Center and baseball games at Fluor Field at the West End. Don't miss Falls Park on the Reedy and the picturesque Liberty Bridge crossing the river. [Find hotel + flight trips in West End](https://expedia.com/go/package/search/FlightHotel/?FromAirport=Downtown%20Columbus,%20Columbus,%20Ohio,%20United%20States%20of%20America&Destination=West%20End&DestID=6348163&DaysInFuture=30&StayLength=7&rfrr=TG.LP.Dest.PKG.Neighborhoods) ![Default Image](https://images.trvl-media.com/media/content/expus/graphics/deals/TE_Clouds_card_r1.jpg?impolicy=fcrop&w=350&h=192&q=medium) ### Hampton-Pinckney Historic District Hampton-Pinckney Historic District is well-liked for its historic sites. If you'd like to do some sightseeing in the greater Greenville area, you might plan a trip to The Children’s Museum of the Upstate or The Peace Center. [Find hotel + flight trips in Hampton-Pinckney Historic District](https://expedia.com/go/package/search/FlightHotel/?FromAirport=Downtown%20Columbus,%20Columbus,%20Ohio,%20United%20States%20of%20America&Destination=Hampton-Pinckney%20Historic%20District&DestID=6348164&DaysInFuture=30&StayLength=7&rfrr=TG.LP.Dest.PKG.Neighborhoods) ### Discover the most popular places to visit in Upstate South Carolina !["Clemson University is an American public, coeducational, land-grant and sea-grant research university located in Clemson, South Carolina, United States.More clemson images:"](https://images.trvl-media.com/place/6127431/81e51bd8-6dfc-4739-9fb0-b15a1329fa3d.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) #### Clemson University Enjoy the collegiate vibe when you visit Clemson University, during your travels in Clemson. Experience the area's theater scene or attend a football game. [](https://expedia.com/Clemson-University-Clemson.d6127431.Vacation-Attraction) ![Falls Park in the middle of downtown! Beautiful place to relax, set up a hammock, play in the water and listen to the falls. ](https://images.trvl-media.com/place/1388/9768cca7-241b-46cc-9044-0389ae1e8a0a.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) #### Falls Park on the Reedy Falls Park on the Reedy is just one of the places to see in Greenville, so why not enjoy the other things to explore during your travels? Experience the acclaimed theater scene or attend a sporting event in this family-friendly area. [](https://expedia.com/Falls-Park-On-The-Reedy-Greenville-Downtown.d6082697.Vacation-Attraction) ![At the foot of the Cross lies my peace... A popular place for weddings in the small open-sided chapel atop the mountain at the YMCA camp. To sit in the pews and look out on the world is a great side of peace. #cross #peace #mountains #SC #relaxing #beautifulday #outdoors #traveljunkie #ktphoenixphotography](https://images.trvl-media.com/place/553248621532656718/82a12a54-2b7c-457d-b071-556ed8fd587d.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) #### Fred W. Symmes Chapel You can find out about the history of Cleveland when you stop by Fred W. Symmes Chapel. Wander the lakeside and forest in this relaxing area. [](https://expedia.com/Fred-W-Symmes-Chapel-Cleveland.d553248621532656718.Vacation-Attraction) ### What to do in Upstate South Carolina ![Just Desserts Tour In Greenville](https://mediaim.expedia.com/localexpert/1351196/8e9eb85a-4aa7-4b2f-88cd-57bc5d997f04.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) #### Just Desserts Tour In Greenville $95 per adult [](https://expedia.com/things-to-do/just-desserts-tour-in-greenville.a1351196.activity-details) ![Greenville: Saturday Morning Breakfast Tour](https://mediaim.expedia.com/localexpert/4536544/2424efd7-807a-4b7b-8d92-2a0a78490524.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) #### Greenville: Saturday Morning Breakfast Tour $90 per adult [](https://expedia.com/things-to-do/greenville-saturday-morning-breakfast-tour.a4536544.activity-details) ![Gorgeous loop around Swan Lake at Furman University.](https://mediaim.expedia.com/localexpert/47647166/7d9e46d8-4054-43e9-85db-de9971fd7898.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) #### Guided E-Bike Tour in Greenville South Carolina with Brunch $105 per adult [](https://expedia.com/things-to-do/guided-e-bike-tour-in-greenville-south-carolina-with-brunch.a47647166.activity-details) [See all activities in Upstate South Carolina](https://expedia.com/things-to-do/search?rid=6057939) ## Upstate South Carolina Hotel Deals ![Hilton Greenville](https://images.trvl-media.com/lodging/1000000/30000/23200/23172/8017eeff_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Hilton Greenville 45 W Orchard Park Dr Greenville SC Fully refundableReserve now, pay when you stay $99 nightly $109 total Apr 12 - Apr 13 Total with taxes and fees 8.2/10 Very Good! (1,001 reviews) Property was very clean throughout stay. Very convenient to getting on/off highway. Minutes from downtown Reviewed on Mar 25, 2026 [](https://expedia.com/Hotel-Search?startDate=4%2F12%2F2026&endDate=4%2F13%2F2026&selected=23172&PinnedHotelID=23172&HadPinnedHotel=true®ionId=6057939) ![Embassy Suites Greenville Golf Resort & Conference Center](https://images.trvl-media.com/lodging/1000000/10000/3300/3223/b0e15e12_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Embassy Suites Greenville Golf Resort & Conference Center 670 Verdae Blvd Greenville SC Fully refundableReserve now, pay when you stay $98 nightly $107 total Apr 5 - Apr 6 Total with taxes and fees 9/10 Wonderful! (1,120 reviews) Clean room. Reviewed on Mar 24, 2026 [](https://expedia.com/Hotel-Search?startDate=4%2F5%2F2026&endDate=4%2F6%2F2026&selected=3223&PinnedHotelID=3223&HadPinnedHotel=true®ionId=6057939) ![Grand Bohemian Lodge Greenville, Autograph Collection](https://images.trvl-media.com/lodging/72000000/71770000/71762700/71762652/6f048029_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Grand Bohemian Lodge Greenville, Autograph Collection 44 EAST CAMPERDOWN WAY Greenville SC Fully refundableReserve now, pay when you stay $349 nightly $383 total Apr 2 - Apr 3 Total with taxes and fees 9.6/10 Exceptional! (466 reviews) Yes, very Reviewed on Mar 21, 2026 [](https://expedia.com/Hotel-Search?startDate=4%2F2%2F2026&endDate=4%2F3%2F2026&selected=71762652&PinnedHotelID=71762652&HadPinnedHotel=true®ionId=6057939) [See all 2,949 properties in Upstate South Carolina](https://expedia.com/Hotel-Search?rfrrid=TG.LP.Hotels.Package&startDate=3%2F27%2F2026&endDate=3%2F28%2F2026®ionId=6057939) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. ## Find the Best Upstate South Carolina Vacation Packages ## Upstate South Carolina Essential Information | Language | English | | --------------- | ------------------------------------- | | Currency | U.S dollars | | Closest Airport | Charlotte-Douglas Intl. Airport (CLT) | ## More vacations you might like ![](https://forever.travel-assets.com/flex/flexmanager/images/2022/06/08/all-inclusive_holidays_US.jpeg?impolicy=fcrop&w=300&h=300&q=mediumHigh) All Inclusive Vacations [](https://expedia.com/lp/theme-vacations/all-inclusive-vacations?rfrr=editorial.All_Inclusive%20Vacations.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2022/10/17/XPC_Beach_Overview_HR_v3.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Beach Vacations [](https://expedia.com/lp/theme-vacations/beach-vacations?rfrr=editorial.Beach_Vacations.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2022/06/08/Family_holidays_US_3_.jpeg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Kid Friendly Vacations [](https://expedia.com/lp/theme-vacations/kid-friendly-vacations?rfrr=editorial.Kid_Friendly%20Vacations.click) 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