Upstate South Carolina Vacations from $341
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Your Upstate South Carolina Vacation
When adventure calls, answer it with a tailor-made vacation package to Upstate South Carolina. Wherever it is you're going and whatever your plans are, prepare to experience a destination with plenty to offer. Start your trip to Upstate South Carolina with a few nights in Greenville visiting popular sights like Falls Park on the Reedy and Bon Secours Wellness Arena. Spartanburg is another city that draws crowds from far and wide. WestGate Mall and Tyger River Park are two of the top places to see in this destination. Find some travel buddies and start packing, because your Upstate South Carolina vacation is just a few clicks away with Expedia.
The Latest Upstate South Carolina vacation packages
Price found within the past 48 hours. Click for updated prices.
Foxhunt at Sapphire Valley
Save 100% on your flight
per person
Aug 22 - Aug 26
found 23 hours ago
Roundtrip flight included
Newark Liberty Intl. Airport (EWR) to Asheville (AVL)
9/10 Wonderful! (402 reviews)
We loved the property. It would be great to have grills by the units but overall fantastic experience!!
Reviewed on Jun 16, 2025
Crowne Plaza Hotel Greenville-I-385-Roper Mtn Rd by IHG
Save 100% on your flight
per person
Sep 14 - Sep 20
found 1 day ago
Roundtrip flight included
Newark Liberty Intl. Airport (EWR) to Greenville (GSP)
8.6/10 Excellent! (1,003 reviews)
The 1st room i was given had a really bad odor. The 2nd was a little more pleasant.
Reviewed on Jun 25, 2025
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Greenville Downtown
2 out of top 10 points of interest in this area
5/5(654 area reviews)
The ample dining options and beautiful river views are top of the list for many visitors to Greenville Downtown. A stop by The Peace Center or Bon Secours Wellness Arena might round out your trip.
Discover the most popular places to visit in Upstate South Carolina
Clemson University
5/5(410 reviews)
Enjoy the collegiate vibe when you visit Clemson University, during your travels in Clemson. Experience the area's theater scene or attend a football game.
Lake Keowee
4.5/5(101 reviews)
Commune with nature and explore the great outdoors at Lake Keowee during your travels in Salem. While you're in the area, wander around the college campus.
Falls Park on the Reedy
4.5/5(583 reviews)
Falls Park on the Reedy is just one of the places to see in Greenville, so why not enjoy the other things to explore during your travels? Experience the great live music or attend a sporting event in this family-friendly area.
What to do in Upstate South Carolina
Epic City Scavenger Hunt in Garden Grove by Operation City Quest
$10
per adult
Greenville on the Go A 1 Hour Rydable Adventure
$59
per adult
Upstate South Carolina Hotel Deals
Hyatt Regency Greenville
220 N Main St, Greenville, SC
Fully refundableReserve now, pay when you stay
$139 nightly
The price is $153 total per night from Jul 6 to Jul 7
$153 total
Jul 6 - Jul 7
Total includes taxes and fees
8.6/10 Excellent! (1,000 reviews)
"Always our preferred place for convenience and consistent amenities"
Reviewed on Jun 22, 2025
La Quinta Inn & Suites by Wyndham Greenville Haywood
65 W Orchard Park Dr, Greenville, SC
Fully refundableReserve now, pay when you stay
$70 nightly
The price is $77 total per night from Jul 1 to Jul 2
$77 total
Jul 1 - Jul 2
Total includes taxes and fees
7.2/10 Good! (1,001 reviews)
"Still a fine value for money hotel, with all features being average plus at worst. One negative (other than forgetting soaps in the room) is that there were no grab bars by the toilet in the room, which proved to be a difficult experience for us."
Reviewed on Jun 24, 2025
Crowne Plaza Hotel Greenville-I-385-Roper Mtn Rd by IHG
851 Congaree Rd, Greenville, SC
Fully refundable
$107 nightly
The price is $118 total per night from Jun 30 to Jul 1
$118 total
Jun 30 - Jul 1
Total includes taxes and fees
8.4/10 Very Good! (1,000 reviews)
"Very nice and clean everyone was real nice"
Reviewed on Jun 22, 2025
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Find the Best Upstate South Carolina Vacation Packages
Upstate South Carolina Essential Information
Language | English |
|---|---|
Currency | U.S dollars |
Closest Airport | Charlotte-Douglas Intl. Airport (CLT) |
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* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.