Upstate South Carolina Vacations from $404

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Your Upstate South Carolina Vacation

When adventure calls, answer it with a tailor-made vacation package to Upstate South Carolina. Wherever it is you're going and whatever your plans are, prepare to experience a destination with plenty to offer. Start your trip to Upstate South Carolina with a few nights in Greenville visiting popular sights like Falls Park on the Reedy and Bon Secours Wellness Arena. Spartanburg is another city that draws crowds from far and wide. WestGate Mall and Tyger River Park are two of the top places to see in this destination. Find some travel buddies and start packing, because your Upstate South Carolina vacation is just a few clicks away with Expedia.

The Latest Upstate South Carolina vacation packages

Price found within the past 48 hours. Click for updated prices.
Holiday Inn Asheville East-Blue Ridge PKWY by IHG
Hilton Garden Inn Asheville Downtown
Grand Bohemian Lodge Asheville, Autograph Collection®
Kimpton Hotel Arras by IHG
The Restoration Asheville
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Where to stay in Upstate South Carolina

Find the best Upstate South Carolina areas and neighborhoods for the activities you enjoy most. Learn more about Upstate South Carolina

Discover the most popular places to visit in Upstate South Carolina

What to do in Upstate South Carolina

Upstate South Carolina Hotel Deals

Crowne Plaza Hotel Greenville-I-385-Roper Mtn Rd by IHG

Crowne Plaza Hotel Greenville-I-385-Roper Mtn Rd by IHG

3.5 out of 5
851 Congaree Rd, Greenville, SC
Fully refundable
$95 nightly
The price is $105 total per night from Aug 31 to Sep 1
$105 total
Aug 31 - Sep 1
Total with taxes and fees
8.4/10 Very Good! (1,000 reviews)
"Great hotel , would stay again ."

Reviewed on Aug 16, 2025

Crowne Plaza Hotel Greenville-I-385-Roper Mtn Rd by IHG
Hyatt Regency Greenville

Hyatt Regency Greenville

3.5 out of 5
220 N Main St, Greenville, SC
Fully refundableReserve now, pay when you stay
$139 nightly
The price is $153 total per night from Sep 1 to Sep 2
$153 total
Sep 1 - Sep 2
Total with taxes and fees
8.6/10 Excellent! (1,002 reviews)
"great"

Reviewed on Aug 21, 2025

Hyatt Regency Greenville
Hilton Greenville

Hilton Greenville

3.5 out of 5
45 W Orchard Park Dr, Greenville, SC
Fully refundableReserve now, pay when you stay
$90 nightly
The price is $99 total per night from Sep 4 to Sep 5
$99 total
Sep 4 - Sep 5
Total with taxes and fees
8/10 Very Good! (1,008 reviews)
"It was a very well kept hotel."

Reviewed on Aug 22, 2025

Hilton Greenville
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

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* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.