Upstate South Carolina Vacations from $640
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Your Upstate South Carolina Vacation
When adventure calls, answer it with a tailor-made vacation package to Upstate South Carolina. Wherever it is you're going and whatever your plans are, prepare to experience a destination with plenty to offer. Start your trip to Upstate South Carolina with a few nights in Greenville visiting popular sights like Falls Park on the Reedy and Bon Secours Wellness Arena. Spartanburg is another city that draws crowds from far and wide. WestGate Mall and Tyger River Park are two of the top places to see in this destination. Find some travel buddies and start packing, because your Upstate South Carolina vacation is just a few clicks away with Expedia.
The Latest Upstate South Carolina vacation packages
Price found within the past 48 hours. Click for updated prices.
Hilton Garden Inn Asheville Downtown
Downtown Asheville
$736
per person
Oct 16 - Oct 19
found 1 day ago
Roundtrip flight included
Newark Liberty Intl. Airport (EWR) to Asheville (AVL)
9.2/10 Wonderful! (950 reviews)
I was very impressed with the quality of this Hilton Garden Inn hotel. Very clean and comfy.
Reviewed on Aug 10, 2026
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See all available trips from Columbus to Upstate South Carolina
View all tripsWhere to stay in Upstate South Carolina
Find the best Upstate South Carolina areas and neighborhoods for the activities you enjoy most. Learn more about Upstate South Carolina
Greenville Downtown
2 out of top 10 points of interest in this area
The ample dining options and beautiful river views are top of the list for many visitors to Greenville Downtown. A stop by The Peace Center or Bon Secours Wellness Arena might round out your trip.
Nicholtown
If you're spending some time in Nicholtown, Swamp Rabbit Trail and Pleasantburg Shopping Center are top sights worth seeing.
West End
Arts and entertainment thrive in this Greenville neighborhood, with cultural events at the Peace Center and baseball games at Fluor Field at the West End. Don't miss Falls Park on the Reedy and the picturesque Liberty Bridge crossing the river.
Overbrook Historic District
While Overbrook Historic District might not have many sights to explore, venturing just a little farther will lead you to top things to see and do like Beattie House and Bon Secours Wellness Arena.
Hampton-Pinckney Historic District
Hampton-Pinckney Historic District is well-liked for its historic sites. If you'd like to do some sightseeing in the greater Greenville area, you might plan a trip to The Children’s Museum of the Upstate or The Peace Center.
Stay near popular Upstate South Carolina attractions
Clemson University
9.6/10 (1,439 reviews)
Walk around the campus of Clemson University, a top university in Clemson. Experience the area's theater scene or attend a football game.
Falls Park on the Reedy
9.6/10 (2,661 reviews)
Falls Park on the Reedy is just one of the places to see in Greenville, so why not enjoy the other things to explore during your travels? Experience the acclaimed theater scene or attend a sporting event in this family-friendly area.
Photo by Karyn Thompson
Fred W. Symmes Chapel
9.8/10 (29 reviews)
You can find out about the history of Cleveland when you stop by Fred W. Symmes Chapel. Wander the lakeside and forest in this relaxing area.
Bon Secours Wellness Arena
8.6/10 (1,219 reviews)
Catch an event at Bon Secours Wellness Arena during your trip to Greenville. Stroll along the riverfront or experience the acclaimed theater scene in this family-friendly area.
Greenville Convention Center
8.4/10 (571 reviews)
Learn about the events happening at Greenville Convention Center during your trip to Greenville. Attend a sporting event or visit the shops in this family-friendly area.
Haywood Mall
8.8/10 (1,681 reviews)
During your trip to Greenville, you can browse for the perfect souvenirs at Haywood Mall. Experience the great live music or attend a sporting event in this family-friendly area.
What to do in Upstate South Carolina
Upstate South Carolina Hotel Deals
Crowne Plaza Hotel Greenville-I-385-Roper Mtn Rd by IHG
851 Congaree Rd Greenville SC
Fully refundable
$99 nightly
$110 total
Aug 16 - Aug 17
Total with taxes and fees
8.6/10 Excellent! (1,016 reviews)
"I have no complaints about the facility. It was clean and well placed. The staff was gracious and helpful."
Reviewed on Aug 9, 2026
Hyatt Regency Greenville
220 N Main St Greenville SC
Fully refundableReserve now, pay when you stay
$157 nightly
$172 total
Sep 6 - Sep 7
Total with taxes and fees
Hyatt Place Greenville/Haywood
40 W Orchard Park Dr Greenville SC
Fully refundableReserve now, pay when you stay
$82 nightly
$91 total
Sep 7 - Sep 8
Total with taxes and fees
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Find the Best Upstate South Carolina Vacation Packages
Upstate South Carolina Essential Information
Language | English |
|---|---|
Currency | U.S dollars |
Closest Airport | Charlotte-Douglas Intl. Airport (CLT) |
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- Fluor Field at the West End
- The Children’s Museum of the Upstate
- Golden Lanes and Golden Skate
- Lakeside Park
- Gatlin Park
- Bon Secours Wellness Arena
- Mauldin Vacations
- Discovery Island Water Park
- Falls Park on the Reedy
- Greenville Vacations
- Visit Greenville
- Terrace Shopping Center
- Greenville Zoo
- Visit Upstate South Carolina
- Frankie's Fun Park
- Visit Greenville Downtown
- Sirrine Stadium
- Simpsonville Vacations
- Gravitopia Trampoline Arena
- Old Towne Shopping Center
- 7th Inning Splash Waterpark
- Lemans Karting
- Southern Wesleyan University Greenville Education Center
- Museum and Library of Confederate History
- Haywood Mall
- Fred W. Symmes Chapel
- Roper Mountain Science Center
- The Peace Center
- Prisma Health Greenville Memorial Hospital
- Conestee Nature Preserve
- Rockwood Park
- Christ Episcopal Church
- Mcalister Square
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.
